Abstract:High entropy alloys (HEAs) have attracted extensive attention due to their excellent properties, such as high strength, high hardness, high toughness, high wear resistance, high radiation resistance, high corrosion resistance, high resistance, high heat resistance, which are expected to be used in important fields such as nuclear energy and aerospace, as well as major equipment. The experimental studies on the preparation, microstructure and properties of HEAs show that their unique properties depend on the high entropy effect, lattice distortion and diffusion hysteresis. At the micro-scale and macro-scale, theoretical models and numerical simulations provide a method for studying the micro mechanism and mechanical properties of HEAs. Establishing the connection from the microstructure and deformation mechanism of HEAs to the unique macroscopic mechanical properties is a multi-scale scientific problem. Recently, based on experimental observation, using multi-scale theory and simulation (first principle method, molecular dynamics, discrete dislocation dynamics, crystal plastic finite element, microstructure dependent theoretical model), the stacking energy, elastic modulus, diffusion coefficient and phase stability of HEAs are studied, and then the deformation and strengthening mechanisms of HEAs are revealed. In this paper, the research progress of multi-scale calculation on mechanical properties and deformation behavior of HEAs is reviewed, and in situ deformation experiment, high-throughput technology and machine learning in HEA is briefly prospected.